LieszLab - Stroke-Immunology
I have been working on the topic of brain-immune interaction after acute brain injuries for more than 10 years and am fascinated by the interaction of these two highly complex super-organisms. My scientific goal is to make new discoveries that will lead to therapies for the benefit of stroke patients. Therefore, we try in my laboratory to combine the use of cutting-edge methodologies and innovative research ideas with a focus on the translational relevance.
Key research achievements include the first report on the neuroprotective role of regulatory T cells in stroke (Nat Med, 2009) which has been reproduced over 20 times. We provided the first description of a bi-directional link between the brain and gut microbiota via immune-mechanisms in acute brain injury (J Neurosci, 2016). Our work on blocking leukocyte brain invasion by Anti-CD49d antibodies (Brain, 2011 and Science Transl Med, 2015) has led to already two completed clinical Phase II studies.
|2016_____________||Habilitation on the topic “Immunological Mechanisms in Acute Brain Ischemia”|
|2010 - 2016||Residency in Clinical Neurology at the Department of Neurology in Heidelberg (Prof. Dr. W. Hacke) and Munich (Prof. Dr. M. Dieterich)|
|2006 - 2010||Medical thesis at the Department of Neurology (supervisor: Dr. R. Veltkamp), University Heidelberg, Germany (summa cum laude)|
|2006 - 2009||Training in Experimental Immunology, Department of Molecular Immunology (Dr. E. Suri-Payer), German Center for Cancer Research (DKFZ), Heidelberg|
|2003 - 2010||Medical studies at the Universities Würzburg and Heidelberg|
Awards & honors
|2004 - 2010||Scholar of the Klaus Murmann Fellowship Program
|2013_____________||Postdoctoral scholarship award, Daimler-Benz Foundation|
|2013||Independent group leader award - Clinician Scientist Program by the Cluster for Systems Neurology (SyNergy)|
|2015||Niels Lassen Award Finalist, International Society of Cerebral Blood Flow and Metabolism|
|2015||Young Investigator Award, European Stroke Organization|
|2018||Roth S, Singh V, Tiedt S, [...] Harris HE, Engelhardt B, Bianchi ME, Vivien D, Bernhagen J, Dichgans M, Liesz A Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Science Translational Medicine, (2018)|
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