Our methodical spectrum covers diverse brain ischemia models, transgenic animal models, a broad spectrum of cutting-edge immunological techniques as well as histological, biomolecular and behavioral analysis tools.
A focus of our work is the role of pro- and anti-inflammatory lymphocyte subpopulations in stroke and their neurotoxic and – protective functions. Following our previous work in this field (e.g. Nature Medicine, 2009, The Journal of Neuroscience, 2013) we have recently characterized a key role of the intestinal microbiome in modulating lymphocyte function after stroke (The Journal of Neuroscience, 2016).
Another focus of our research is the migration of pro-inflammatory leukocytes to the ischemic brain (Brain, 2011). Here, we are currently investigating pathophysiological mechanisms of leukocyte-endothelial interaction and novel therapeutic approaches for translational use (Science Translational Medicine, 2015).
A third research area investigatesalarmin-driven mechanisms of peripheral immune alterations after brain ischemia. We aim to characterize alarmins—humoral mediators released by the necrotic brain tissue—as modulators of the systemic immune system (The Journal of Neuroscience, 2015)
Contact: PD Dr. med. Arthur Liesz