GokceLab - Systems Neuroscience – Cell Diversity
We use experimental and computational approaches to study the connectivity of the basal ganglia circuit to identify regulators of the vascular-glial-neuron triad connections during health and neurological disorders.
The neuronal network is a highly organized dynamic system that generates our thoughts, actions and feelings. Such a complex network requires a cell type-specific recognition code that identifies the right connections and alters them through experience.
Our laboratory seeks to understand how neuron-glia-vascular communications are regulated by cell type-specific adhesion molecules during both health and disease. The importance of cell adhesions in brain function is highlighted by the fact that mutations in cell adhesion genes are associated with vascular, neurodegenerative and psychiatric disorders.
We use a combination of single cell transcriptomics, live imaging and molecular approaches to elucidate the cellular and molecular mechanisms regulating the interconnected vascular-glial-neuron triad.
Ozgun Gokce received his PhD in EPFL, Switzerland. As a postdoctoral fellow, he joined the laboratory of nobel laureat Thomas C. Südhof at Stanford University, USA. He is recipient of 2 NARSAD awards and a NIH Pathway to Independence Award (K99/R00).
Contact: Dr. Ozgun Gokce