An international research consortium studying 520,000 individuals from around the world has identified 22 new genetic risk factors for stroke, thus tripling the number of gene regions known to affect stroke risk. The results demonstrate shared genetic influences with multiple related vascular conditions, especially blood pressure, but also coronary artery disease, venous thromboembolism and others. Linking these results with extensive biological databases provides novel clues on stroke mechanisms and illustrates the potential of genetics to identify drug targets for stroke therapy.
The results of the largest genetic study on stroke thus far were published online in the journal Nature Genetics today. The study was based on DNA samples of 520,000 European, North- and South American, Asian, African, and Australian participants of whom 67,000 had a stroke. These were derived from 29 large studies.
From the millions of genetic variants analyzed, 32 independent genomic regions were shown to be associated with stroke of which two thirds are novel.
Professor Martin Dichgans
Institute for Stroke and Dementia Research
Klinikum der Universität München. Ludwig-Maximilians-University (LMU), Munich, Germany
Feodor-Lynen-Straße 17, D-81377 München
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